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EYE-RISKEYE-RISK

EYE-RISK Publications

2021-2023

  • Systemic Metabolomics in a Framework of Genetics and Lifestyle in Age-Related Macular Degeneration
    Thee, E. F., Acar, I. E., Colijn, J. M., Meester-Smoor, M. A., Verzijden, T., Baart, S. J., Jarboui, M. A., Fauser, S., Hoyng, C. B., Ueffing, M., den Hollander, A. I., Klaver, C. C. W., European Eye Epidemiology, C., and Project, E.-R. (2023) Metabolites 13 doi: https://doi.org/10.3390/metabo13060701
  • The Phenotypic Course of Age-Related Macular Degeneration for ARMS2/HTRA1: The EYE-RISK Consortium
    Thee, E. F., Colijn, J. M., Cougnard-Gregoire, A., Meester-Smoor, M. A., Verzijden, T., Hoyng, C. B., Fauser, S., Hense, H. W., Silva, R., Creuzot-Garcher, C., Ueffing, M., Delcourt, C., den Hollander, A. I., Klaver, C. C. W., European Eye Epidemiology, C., and Project, E.-R. (2022) Ophthalmology 129, 752-764. doi: https://doi.org/10.1016/j.ophtha.2022.02.026.
  • Enlargement of Geographic Atrophy From First Diagnosis to End of Life
    Colijn, J. M., Liefers, B., Joachim, N., Verzijden, T., Meester-Smoor, M. A., Biarnes, M., Mones, J., de Jong, P., Vingerling, J. R., Mitchell, P., Sanchez, C. I., Wang, J. J., Klaver, C. C. W., Eye, N. E. D. R. C., and Consortium, E.-R. (2021) JAMA Ophthalmol 139, 743-750. doi: https://doi.org/10.1001/jamaophthalmol.2021.1407.

2020

  • Genetic risk, lifestyle, and AMD in Europe. The EYE-RISK consortium
    Colijn, J. M., Meester, M., Verzijden, T., de Breuk, A., Silva, R., Merle, B. M. J., Cougnard-Gregoire, A., Hoyng, C. B., Fauser, S., Coolen, T., Creuzot-Garcher, C., Hense, H. W., Ueffing, M., Delcourt, C., Hollander, A. I. D., Klaver, C. C. W., and Consortium, E.-R. (2020) Ophthalmology  doi: https://doi.org/10.1016/j.ophtha.2020.11.024
  • Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degeneration: The EYE-RISK Consortium
    Acar, I. E., Lores-Motta, L., Colijn, J. M., Meester-Smoor, M. A., Verzijden, T., Cougnard-Gregoire, A., Ajana, S., Merle, B. M. J., de Breuk, A., Heesterbeek, T. J., van den Akker, E., Daha, M. R., Claes, B., Pauleikhoff, D., Hense, H. W., van Duijn, C. M., Fauser, S., Hoyng, C. B., Delcourt, C., Klaver, C. C. W., Galesloot, T. E., den Hollander, A. I., and Consortium, E.-R. (2020) Ophthalmology 127, 1693-1709. doi: https://doi.org/10.1016/j.ophtha.2020.06.020
  • A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium
    Emri, E., Kortvely, E., Dammeier, S., Klose, F., Simpson, D., Consortium, E. R., Den Hollander, A. I., Ueffing, M., and Lengyel, I. (2020) Nutrients 12 doi: https://doi.org/10.3390/nu12103051.
  • Predicting progression to advanced age-related macular degeneration from clinical, genetic and lifestyle factors using machine learning
    Ajana, S., Cougnard-Gregoire, A., Colijn, J. M., Merle, B. M., Verzijden, T., de Jong, P. T., Hofman, A., Vingerling, J. R., Hejblum, B. P., Korobelnik, J. F., Meester-Smoor, M. A., Ueffing, M., Jacqmin-Gadda, H., Klaver, C. C., Delcourt, C., and Consortium, E.-R. (2020) Ophthalmology  doi: https://doi.org/10.1016/j.ophtha.2020.08.031.
  • Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium
    de Breuk, A., Acar, I. E., Kersten, E., Schijvenaars, M., Colijn, J. M., Haer-Wigman, L., Bakker, B., de Jong, S., Meester-Smoor, M. A., Verzijden, T., Missotten, T., Mones, J., Biarnes, M., Pauleikhoff, D., Hense, H. W., Silva, R., Nunes, S., Melo, J. B., Fauser, S., Hoyng, C. B., Ueffing, M., Coenen, M. J. H., Klaver, C. C. W., den Hollander, A. I., and Consortium, E.-R. (2020) Ophthalmology  doi: https://doi.org/10.1016/j.ophtha.2020.07.037.
  • Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells
    Armento, A., Honisch, S., Panagiotakopoulou, V., Sonntag, I., Jacob, A., Bolz, S., Kilger, E., Deleidi, M., Clark, S., and Ueffing, M. (2020) Sci Rep 10, 10320. doi: https://doi.org/10.1038/s41598-020-67292-z.
  • Genotype and phenotype-based subgroups in geographic atrophy secondary to age-related macular degeneration. The EYE-RISK Consortium
    Biarnes, M., Colijn, J. M., Sousa, J., Ferraro, L. L., Garcia, M., Verzijden, T., Meester-Smoor, M. A., Delcourt, C., Klaver, C. C. W., den Hollander, A. I., Lengyel, I., Peto, T., Mones, J., and Consortium, E.-R. (2020) Ophthalmol Retina  doi: 10.1016/j.oret.2020.04.014.
  • Risk factors for progression of age-related macular degeneration
    Heesterbeek, T. J., Lores-Motta, L., Hoyng, C. B., Lechanteur, Y. T. E., and den Hollander, A. I. (2020) Ophthalmic Physiol Opt 40, 140-170. doi: 10.1111/opo.12675.
  • Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration
    Pool, F. M., Kiel, C., Serrano, L., and Luthert, P. J. (2020) NPJ Aging Mech Dis 6, 2. doi: 10.1038/s41514-019-0039-5.

2019

  1. On the origin of proteins in human drusen: The meet, greet and stick hypothesis
    Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P. J., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J., and Lengyel, I. (2019) Prog Retin Eye Res 70, 55-84. doi: 10.1016/j.preteyeres.2018.12.003.
  2. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia
    Colijn, J. M., den Hollander, A. I., Demirkan, A., Cougnard-Gregoire, A., Verzijden, T., Kersten, E., Meester-Smoor, M. A., Merle, B. M. J., Papageorgiou, G., Ahmad, S., Mulder, M. T., Costa, M. A., Benlian, P., Bertelsen, G., Bron, A. M., Claes, B., Creuzot-Garcher, C., Erke, M. G., Fauser, S., Foster, P. J., Hammond, C. J., Hense, H. W., Hoyng, C. B., Khawaja, A. P., Korobelnik, J. F., Piermarocchi, S., Segato, T., Silva, R., Souied, E. H., Williams, K. M., van Duijn, C. M., Delcourt, C., Klaver, C. C. W., European Eye Epidemiology, C., and Consortium, E.-R. (2019) Ophthalmology 126, 393-406. doi: 10.1016/j.ophtha.2018.09.045.
  3. Intake of Vegetables, Fruit, and Fish is Beneficial for Age-Related Macular Degeneration
    de Koning-Backus, A. P. M., Buitendijk, G. H. S., Kiefte-de Jong, J. C., Colijn, J. M., Hofman, A., Vingerling, J. R., Haverkort, E. B., Franco, O. H., and Klaver, C. C. W. (2019) Am J Ophthalmol 198, 70-79. doi: 10.1016/j.ajo.2018.09.036.
  4. A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
    Handa, J. T., Bowes Rickman, C., Dick, A. D., Gorin, M. B., Miller, J. W., Toth, C. A., Ueffing, M., Zarbin, M., and Farrer, L. A. (2019) Nat Commun 10, 3347. doi: 10.1038/s41467-019-11262-1.
  5. Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration
    Heesterbeek, T. J., de Jong, E. K., Acar, I. E., Groenewoud, J. M. M., Liefers, B., Sanchez, C. I., Peto, T., Hoyng, C. B., Pauleikhoff, D., Hense, H. W., and den Hollander, A. I. (2019) Sci Rep 9, 6611. doi: 10.1038/s41598-019-43144-3.
  6. Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway
    Kersten, E., Dammeier, S., Ajana, S., Groenewoud, J. M. M., Codrea, M., Klose, F., Lechanteur, Y. T., Fauser, S., Ueffing, M., Delcourt, C., Hoyng, C. B., de Jong, E. K., den Hollander, A. I., and Consortium, E.-R. (2019) PLoS One 14, e0218457. doi: 10.1371/journal.pone.0218457.
  7. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium
    Merle, B. M. J., Colijn, J. M., Cougnard-Gregoire, A., de Koning-Backus, A. P. M., Delyfer, M. N., Kiefte-de Jong, J. C., Meester-Smoor, M., Feart, C., Verzijden, T., Samieri, C., Franco, O. H., Korobelnik, J. F., Klaver, C. C. W., Delcourt, C., and Consortium, E.-R. (2019) Ophthalmology 126, 381-390. doi: 10.1016/j.ophtha.2018.08.006.
  8. The clinical relevance of visualising the peripheral retina
    Quinn, N., Csincsik, L., Flynn, E., Curcio, C. A., Kiss, S., Sadda, S. R., Hogg, R., Peto, T., and Lengyel, I. (2019) Prog Retin Eye Res 68, 83-109. doi: 10.1016/j.preteyeres.2018.10.001.
  9. Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
    Valdes-Sanchez, L., Calado, S. M., de la Cerda, B., Aramburu, A., Garcia-Delgado, A. B., Massalini, S., Montero-Sanchez, A., Bhatia, V., Rodriguez-Bocanegra, E., Diez-Lloret, A., Rodriguez-Martinez, D., Chakarova, C., Bhattacharya, S. S., and Diaz-Corrales, F. J. (2019) Mol Med 26, 1. doi: 10.1186/s10020-019-0124-z.
  10. Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum
    Verbakel, S. K., van Huet, R. A. C., den Hollander, A. I., Geerlings, M. J., Kersten, E., Klevering, B. J., Klaver, C. C. W., Plomp, A. S., Wesseling, N. L., Bergen, A. A. B., Nikopoulos, K., Rivolta, C., Ikeda, Y., Sonoda, K. H., Wada, Y., Boon, C. J. F., Nakazawa, T., Hoyng, C. B., and Nishiguchi, K. M. (2019) Invest Ophthalmol Vis Sci 60, 1192-1203. doi: 10.1167/iovs.18-26084.

2018

  1. Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration
    Arya, S., Emri, E., Synowsky, S. A., Shirran, S. L., Barzegar-Befroei, N., Peto, T., Botting, C. H., Lengyel, I., and Stewart, A. J. (2018) Exp Eye Res 172, 21-29. doi: 10.1016/j.exer.2018.03.023.
  2. Precision medicine for age-related macular degeneration: current developments and prospects
    Biarnes, M., Vassiliev, V., Nogoceke, E., Emri, E., Rodriguez-Bocanegra, E., Ferraro, L., Garcia, M., Fauser, S., Mones, J., Lengyel, I., and Peto, T. (2018) Expert Review of Precision Medicine and Drug Development 3, 249-263. doi: 10.1080/23808993.2018.1502037.
  3. Metabolomics and Age-Related Macular Degeneration
    Brown, C. N., Green, B. D., Thompson, R. B., den Hollander, A. I., Lengyel, I., and consortium, E.-R. (2018) Metabolites 9 doi: 10.3390/metabo9010004.
  4. Is 'good' cholesterol bad for Age-related Macular Degeneration? Evidence from the EYE-RISK and E3 Consortia
    Colijn, J. M., Kersten, E., Demirkan, A., Cougnard-Gregoire, A., Verzijden, T., Meester, M. A., Merle, B. M. J., Vingerling, J. R., Den Hollander, A. I., van Duijn, C., DelCourt, C., and Klaver, C. C. W. (2018) Investigative Ophthalmology & Visual Science 59.
  5. Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1, a Component of Bruch's Membrane
    Corominas, J., Colijn, J. M., Geerlings, M. J., Pauper, M., Bakker, B., Amin, N., Lores Motta, L., Kersten, E., Garanto, A., Verlouw, J. A. M., van Rooij, J. G. J., Kraaij, R., de Jong, P., Hofman, A., Vingerling, J. R., Schick, T., Fauser, S., de Jong, E. K., van Duijn, C. M., Hoyng, C. B., Klaver, C. C. W., and den Hollander, A. I. (2018) Ophthalmology 125, 1433-1443. doi: 10.1016/j.ophtha.2018.03.040.
  6. Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications
    Dammeier, S., Martus, P., Klose, F., Seid, M., Bosch, D., D'Alvise, J., Ziemssen, F., Dimopoulos, S., and Ueffing, M. (2018) Transl Vis Sci Technol 7, 22. doi: 10.1167/tvst.7.6.22.
  7. Geographic distribution of rare variants associated with age-related macular degeneration
    Geerlings, M. J., Kersten, E., Groenewoud, J. M. M., Fritsche, L. G., Hoyng, C. B., de Jong, E. K., and den Hollander, A. I. (2018) Mol Vis 24, 75-82.
  8. Genetic screening for macular dystrophies in patients clinically diagnosed with dry age-related macular degeneration
    Kersten, E., Geerlings, M. J., Pauper, M., Corominas, J., Bakker, B., Altay, L., Fauser, S., de Jong, E. K., Hoyng, C. B., and den Hollander, A. I. (2018) Clin Genet 94, 569-574. doi: 10.1111/cge.13447.
  9. Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration
    Kersten, E., Paun, C. C., Schellevis, R. L., Hoyng, C. B., Delcourt, C., Lengyel, I., Peto, T., Ueffing, M., Klaver, C. C. W., Dammeier, S., den Hollander, A. I., and de Jong, E. K. (2018) Surv Ophthalmol 63, 9-39. doi: 10.1016/j.survophthal.2017.05.003.
  10. Geographic atrophy phenotype identification by cluster analysis
    Mones, J., and Biarnes, M. (2018) Br J Ophthalmol 102, 388-392. doi: 10.1136/bjophthalmol-2017-310268.
  11. The Rate of Progression of Geographic Atrophy Decreases With Increasing Baseline Lesion Size Even After the Square Root Transformation
    Mones, J., and Biarnes, M. (2018) Transl Vis Sci Technol 7, 40. doi: 10.1167/tvst.7.6.40.
  12. The effects of zinc supplementation on primary human retinal pigment epithelium
    Pao, P. J., Emri, E., Abdirahman, S. B., Soorma, T., Zeng, H. H., Hauck, S. M., Thompson, R. B., and Lengyel, I. (2018) J Trace Elem Med Biol 49, 184-191. doi: 10.1016/j.jtemb.2018.02.028.
  13. Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration
    Tan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., Li, M., Messinger, J. D., Dolz-Marco, R., Lei, J., Nittala, M. G., Sadda, S. R., Lengyel, I., Freund, K. B., and Curcio, C. A. (2018) Sci Transl Med 10 doi: 10.1126/scitranslmed.aat4544.
  14. A new perspective on lipid research in age-related macular degeneration
    van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., Delcourt, C., Rodrigez-Bocanegra, E., Biarnes, M., Luthert, P. J., Ueffing, M., Klaver, C. C. W., Nogoceke, E., den Hollander, A. I., and Lengyel, I. (2018) Prog Retin Eye Res 67, 56-86. doi: 10.1016/j.preteyeres.2018.04.006.

2017

  1. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future
    Colijn, J. M., Buitendijk, G. H. S., Prokofyeva, E., Alves, D., Cachulo, M. L., Khawaja, A. P., Cougnard-Gregoire, A., Merle, B. M. J., Korb, C., Erke, M. G., Bron, A., Anastasopoulos, E., Meester-Smoor, M. A., Segato, T., Piermarocchi, S., de Jong, P., Vingerling, J. R., Topouzis, F., Creuzot-Garcher, C., Bertelsen, G., Pfeiffer, N., Fletcher, A. E., Foster, P. J., Silva, R., Korobelnik, J. F., Delcourt, C., Klaver, C. C. W., consortium, E.-R., and European Eye Epidemiology, c. (2017) Ophthalmology 124, 1753-1763. doi: 10.1016/j.ophtha.2017.05.035.
  2. Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene
    Kersten, E., Geerlings, M. J., den Hollander, A. I., de Jong, E. K., Fauser, S., Peto, T., and Hoyng, C. B. (2017) JAMA Ophthalmol 135, 1037-1044. doi: 10.1001/jamaophthalmol.2017.3195.
  3. Simple and complex retinal dystrophies are associated with profoundly different disease networks
    Kiel, C., Lastrucci, C., Luthert, P. J., and Serrano, L. (2017) Sci Rep 7, 41835. doi: 10.1038/srep41835.
  4. Drusen Ooze: A Novel Hypothesis in Geographic Atrophy
    Mones, J., Garcia, M., Biarnes, M., Lakkaraju, A., and Ferraro, L. (2017) Ophthalmol Retina 1, 461-473. doi: 10.1016/j.oret.2017.02.006.
  5. Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
    Pilgrim, M. G., Lengyel, I., Lanzirotti, A., Newville, M., Fearn, S., Emri, E., Knowles, J. C., Messinger, J. D., Read, R. W., Guidry, C., and Curcio, C. A. (2017) Invest Ophthalmol Vis Sci 58, 708-719. doi: 10.1167/iovs.16-21060.

2016

  1. The unconventional secretion of ARMS2
    Kortvely, E., Hauck, S. M., Behler, J., Ho, N., and Ueffing, M. (2016) Hum Mol Genet 25, 3143-3151. doi: 10.1093/hmg/ddw162.
  2. HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo
    Trifunovic, D., Arango-Gonzalez, B., Comitato, A., Barth, M., Del Amo, E. M., Kulkarni, M., Sahaboglu, A., Hauck, S. M., Urtti, A., Arsenijevic, Y., Ueffing, M., Marigo, V., and Paquet-Durand, F. (2016) Hum Mol Genet 25, 4462-4472. doi: 10.1093/hmg/ddw275.