In the study Drusen ooze: A novel Hypothesis in Geographic Atrophy, recently published in the scientific journal Ophthalmology Retina, Dr. Jordi Monés, MD PhD, Director of the Institut de la Màcula and Medical Director of the Barcelona Macula Foundation, together with Míriam Garcia, MSc, Dr. Marc Biarnés, PhD, Dr. Aparna Lakkaraju, PhD, and Dra. Lucía Ferraro, MD, describe new findings related to drusen and propose a mechanism of progression to geographic atrophy (GA) in patients with age-related macular degeneration (AMD). This discovery was made during research work undertaken during the EYE-RISK project.
AMD is the leading cause of irreversible sight loss in developed countries. It is an inflammatory, chronic and progressive condition that gives rise to a loss of central vision due to the degeneration of the macula (the central region of the retina).
GA is associated with loss of visual acuity due to loss of retinal pigment epithelium (RPE) and photoreceptors and is a consequence of the progression of AMD. Through the use of imaging techniques like optical coherence tomography (OCT), the aim is to find out more about the earliest events in the atrophy process in order to understand its mechanisms better and thereby be in a better position to seek a way to halt or prevent atrophy progression. In the genesis and the atrophy process there are still many mechanisms and processes that are not understood.